Lately everybody and their grandma have become proud armchair epidemiologists, virologists, maskologists, and vaccinologists. If I disagree with something and remind them, “actually I have a license to practice medicine”, sparks can fly. Very disconcerting.

If a clinical trial endpoint is subjective like depression, there must be a blind placebo control group. If you will blast a building and want to measure the damage, you don't need a placebo control group because this is objective. Clearly, a no-blast will show no damage.

Clinical trials require that the data collection is going to be exact. Many a trial fails when the data is audited. This is called Good Clinical Practice. #clinicaltrials

Poor sleep and meds: many people give-up quickly when there is plenty of chance to adjust dose, type, and regimen where a rotation of drug-type is often effective. #insomnia

Medication doses and formulations can differ from country to country. Creative adjustments of dose breaking pills or emptying capsules and close monitoring until the patient moves into a new stable state are good ways to handle this issue. #drugformulation #medications